Demographics and CYP3A4/5 activity of individual human liver samples
Smoking and alcohol use data were obtained from families of the donors. Recent smoking activity is defined as regular use in the 5 years before death. Liver microsomes were prepared and P450 enzyme activity rates were determined as described under Materials and Methods.
Liver Sample No. | Age | Gender | Ethnicity | Recent Smoker? | Alcohol Use? | CYP3A4/5 Activity |
|---|---|---|---|---|---|---|
| yr | pmol/mg protein/min | |||||
| 1 | <1 | M | C | N | N | 448 |
| 2 | <1 | M | H | N | N | 207 |
| 3 | 4 | F | C | N | N | 9890 |
| 4 | 9 | M | C | N | N | 2900 |
| 5 | 17 | M | C | Y | Y | 3620 |
| 6 | 24 | M | C | N | Y | 5580 |
| 7 | 36 | F | C | Y | N | 3940 |
| 8 | 42 | M | C | Y | Y | 268 |
| 9 | 42 | M | C | N | Y | 772 |
| 10 | 43 | M | C | N | Y | 1960 |
| 11 | 49 | M | C | N | Y | 4410 |
| 12 | 49 | F | C | Y | N | 16,900 |
| 13 | 52 | M | C | N | N | 1640 |
| 14 | 54 | F | C | N.D. | N.D. | 1425 |
| 15 | 56 | F | C | Y | N | 20,300 |
| 16 | 59 | M | H | Y | Y | 16,400 |
| 17 | 61 | F | C | Y | N.D. | 765 |
| 18 | 65 | M | AA | N | Y | 9100 |
| 19 | 66 | M | C | N | Y | 888 |
| 20 | 66 | M | C | Y | Y | 201 |
C, Caucasian; H, Hispanic; AA, African American; N.D., not determined.