Enzyme | Probe Drug/Activity | Minimum | Maximum | Variability (-Fold) | Mean Activity Level | S.D. |
---|---|---|---|---|---|---|
pmol/mg protein/min | ||||||
CYP1A2 | 7-Ethoxyresorufin O-dealkylation | 5.9 | 175 | 30 | 39 | 43 |
CYP2A6 | Coumarin 7-hydroxylation | 91.5 | 4000 | 44 | 958 | 1179 |
CYP2B6 | S-Mephenytoin N-demethylation | 13 | 1280 | 98 | 191 | 315 |
CYP2C8 | Paclitaxel 6α-hydroxylation | 37.4 | 2040 | 55 | 512 | 623 |
CYP2C9 | Diclofenac 4′-hydroxylation | 210 | 3530 | 17 | 1748 | 774 |
CYP2C19 | S-Mephenytoin 4′-hydroxylation | 2.69 | 344 | 128 | 94 | 89 |
CYP2D6 | Dextromethorphan O-demethylation | 85.5 | 870 | 10 | 392 | 170 |
CYP2E1 | Chlorzoxazone 6-hydroxylation | 358 | 4270 | 12 | 2057 | 974 |
CYP3A4/5 | Testosterone 6β-hydroxylation | 201 | 20,300 | 101 | 5081 | 6196 |