TABLE 9

Statistical significance of linear correlations among mRNA levels of coregulated xenobiotic metabolism genes after partial regression analysis controlling for HNF4α

Note that significant p values present in Table 7 that are no longer significant in Table 9 represent associations that are abrogated upon controlling for HNF4α variability.






CYP2A6

CYP2B6

CYP2C8

CYP2C9

CYP2C19

MRP2

OATP2

POR
UGT1A1 Co. 0.646* 0.815* 0.820* N.S. N.S. N.S. N.S. 0.473*
Sig. 0.003 0.000 0.000 0.589 0.426 0.092 0.120 0.041
POR Co. N.S. N.S. N.S. N.S. N.S. N.S. N.S.
Sig. 0.058 0.062 0.527 0.949 0.413 0.335 0.415
OATP2 Co. N.S. N.S. N.S. 0.783* 0.913* 0.456*
Sig. 0.321 0.777 0.089 0.000 0.000 0.050
MRP2 Co. N.S. N.S. N.S. N.S. N.S.
Sig. 0.529 0.656 0.283 0.158 0.236
CYP2C19 Co. N.S. N.S. N.S. 0.899*
Sig. 0.506 0.991 0.168 0.000
CYP2C9 Co. N.S. N.S. N.S.
Sig. 0.909 0.980 0.117
CYP2C8 Co. 0.530* 0.703*
Sig. 0.020 0.001
CYP2B6 Co. 0.702*

Sig.
0.001







  • Co., partial correlation coefficient; Sig., significance (p value); N.S., not significant.

  • * p < 0.05. Values of 0 indicate that p < 0.0005.