Statistics of in vitro-in vivo agreement for Vu,brain estimations
The statistical analysis was performed for all 15 compounds. Bias and CIRs indicate the likely range of the difference between the in vitro or in silico estimations of Vu,brain and in vivo values.
Slice | Homogenate | Log D7.4 | |
|---|---|---|---|
| Bias (ratio of in vitro to in vivo estimation) | 1.34 (N.S.) | 1.31 (N.S.) | 0.807 (N.S.) |
| Bias excluding gabapentin | 1.40 (N.S.) | 1.50 (N.S.) | 0.985 (N.S.) |
| 90% CIR | 2.95 | 6.00 | 8.97 |
| 90% CIR excluding gabapentin | 2.96 | 4.91 | 6.02 |
N.S., not significantly different from 1 (P > 0.05).