TABLE 5

Pharmacokinetic parameters of rosuvastatin during constant intravenous infusion into FVB mice and Bcrp1 knockout mice

Each point represents the mean ± S.E. (n = 3).

	C_{p, ss}	CL_{tot, p}	C_{H, ss}	K_{p, H}	V_{bile, ss}	CL_{bile, p}	CL_{bile, H}
	nM	ml/min/kg	nM		pmol/min/kg	ml/min/kg
FVB	1.38 ± 0.28	77.9 ± 13.3	11.5 ± 1.5	8.58 ± 0.77	49.7 ± 1.7	38.7 ± 6.6	4.48 ± 0.63
Bcrp1 ^-/-	2.40 ± 0.09*	41.8 ± 1.6	12.9 ± 2.6	5.35 ± 1.03	5.99 ± 1.26***	2.48 ± 0.46*	0.531 ± 0.205*

C_{p, ss}, plasma steady-state concentration (mean plasma concentration at 120 min); CL_{tot, p}, total plasma clearance calculated by dividing the infusion rate by C_{p, ss}; C_{H, ss}, hepatic steady-state concentration (mean hepatic concentration at 120 min); K_{p, H}, liver/plasma concentration ratio at steady state, which was calculated by dividing the C_{H, ss} value by the C_{p, ss} value; V_{bile, ss}, steady-state biliary excretion rate (mean biliary excretion rate during 90-120 min); CL_{bile, p}, biliary excretion clearance relative to the plasma concentration, which was calculated by dividing the V_{bile, ss} value by the C_{p, ss} value; CL_{bile, H}, biliary excretion clearance relative to the hepatic concentration, which was calculated by dividing the V_{bile, ss} value by the C_{H, ss} value.
↵* P < 0.05.
↵*** P < 0.001.