Reaction | S0.5 | Vmax | nH | ||||||
---|---|---|---|---|---|---|---|---|---|
Control | +Inhibitor | Control | +Inhibitor | Control | +Inhibitor | ||||
μM | min-1 | ||||||||
Midazolam 1′-hydroxylation | 6.2 ± 1.4 | 25.9 ± 1.6 | 3.80 ± 0.39 | 1.63 ± 0.07 | 0.94 ± 0.07 | 1.54 ± 0.08 | |||
Midazolam 4-hydroxylation | 23.5 ± 6.3 | 103 ± 31 | 2.25 ± 0.25 | 2.75 ± 0.76 | 0.88 ± 0.07 | 1.45 ± 0.09 | |||
Diltiazem N-demethylation | 38.2 ± 2.5 | 552 ± 337 | 83.8 ± 1.9 | 126 ± 43 | 0.83 ± 0.03 | 0.90 ± 0.10 |