Assigned Vmax | A → B | B → A | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Jmax | K[prime]m* |
*
| β | Jmax |
*
|
*
| β | |||||||
nmol/min | μM | μM | nmol/min | μM | μM | |||||||||
Case 1 (CLd = 0.01 ml/min) | ||||||||||||||
0.05 nmol/min | 0.0256 | 1.13 | 3.40 | 1.29 | 0.0238 | 1.05 | 3.13 | 1.28 | ||||||
0.5 nmol/min | 0.256 | 1.75 | 18.4 | 1.72 | 0.238 | 1.57 | 17.1 | 1.73 | ||||||
5 nmol/min | 124 | 2.92 × 104 | 2.91 × 104 | 1.00 | 92.4 | 2.17 × 104 | 2.16 × 104 | 1.00 | ||||||
25 nmol/min | 2.81 × 104 | 6.82 × 106 | 6.82 × 106 | 1.00 | 2.65 × 104 | 6.27 × 106 | 6.27 × 106 | 1.00 | ||||||
50 nmol/min | 1.32 × 105 | 3.11 × 107 | 3.11 × 107 | 1.00 | 1.22 × 105 | 2.89 × 107 | 2.89 × 107 | 1.00 | ||||||
Case 2 (CLd = 0.1 ml/min) | ||||||||||||||
0.05 nmol/min | 0.0293 | 1.23 | 1.87 | 1.10 | 0.0205 | 0.858 | 1.26 | 1.08 | ||||||
0.5 nmol/min | 0.293 | 1.37 | 8.20 | 1.53 | 0.205 | 0.927 | 5.59 | 1.51 | ||||||
5 nmol/min | 3.21 | 50.1 | 96.3 | 1.26 | 2.06 | 2.79 | 35.6 | 1.69 | ||||||
25 nmol/min | 199 | 1.32 × 104 | 1.31 × 104 | 1.00 | 267 | 1.77 × 104 | 1.76 × 104 | 1.00 | ||||||
50 nmol/min | 1.09 × 104 | 7.27 × 105 | 7.27 × 105 | 1.00 | 2.20 × 104 | 1.48 × 106 | 1.48 × 106 | 1.00 | ||||||
Case 3 (CLd = 1 ml/min) | ||||||||||||||
0.05 nmol/min | 0.0310 | 1.34 | 1.80 | 1.07 | 0.0189 | 0.812 | 1.05 | 1.05 | ||||||
0.5 nmol/min | 0.310 | 1.43 | 7.63 | 1.51 | 0.189 | 0.846 | 4.52 | 1.47 | ||||||
5 nmol/min | 3.15 | 10.0 | 57.8 | 1.52 | 1.89 | 1.51 | 29.2 | 1.79 | ||||||
25 nmol/min | 1.34 × 107 | 8.60 × 108 | 8.60 × 108 | 1.00 | 1.08 × 105 | 6.93 × 106 | 6.93 × 106 | 1.00 | ||||||
50 nmol/min | 3.41 × 109 | 2.19 × 1011 | 2.19 × 1011 | 1.00 | 4.11 × 109 | 2.64 × 1011 | 2.64 × 1011 | 1.00 |
↵* True Km is 0.5 μM