TABLE 1

Pharmacokinetic parameters of unconjugated silymarin flavonolignans in perfusate of WT and TR rats

Pharmacokinetic parameters of unconjugated silymarin flavonolignans after addition of silymarin (26 μg/ml) to the perfusate. Data are expressed as mean ± S.E.M. (n = 3).


Flavonolignan

C0

AUC

Cl

Clb
WT
TR
WT
TR
WT
TR
WT
TR
μg/ml min·μg/ml ml/min ml/min
SC 4.59 ± 0.34 4.00 ± 0.36 55.66 ± 11.76 47.03 ± 2.15 8.41 ± 1.81 9.20 ± 0.97 0.15 ± 0.04 0.18 ± 0.05
SD 2.81 ± 0.46 2.07 ± 0.57 23.47 ± 8.53 13.99 ± 3.69 9.51 ± 2.85 15.27 ± 4.04 0.23 ± 0.11 0.20 ± 0.03
SA 4.95 ± 0.77 5.21 ± 1.20 31.93 ± 1.70 28.29 ± 3.64 13.35 ± 0.71 15.42 ± 1.58 0.06 ± 0.03 0.01 ± 0.00
SB 6.65 ± 0.71 7.01 ± 1.50 40.95 ± 2.95 40.57 ± 4.82 17.06 ± 0.88 18.04 ± 2.02 0.06 ± 0.03 0.01 ± 0.00
ISA 1.99 ± 0.22 2.12 ± 0.60 10.73 ± 0.92 9.69 ± 1.81 14.76 ± 1.77 18.13 ± 3.02 0.04 ± 0.01 0.02 ± 0.01
ISB
0.87 ± 0.14
0.87 ± 0.23
6.96 ± 1.18
4.47 ± 1.01
9.12 ± 2.10
17.70 ± 3.40
0.06 ± 0.00
0.05 ± 0.02
  • Cl, clearance of unconjugated flavonolignans from perfusate; Clb, biliary clearance of the unconjugated flavonolignans.