TABLE 1

Formation rates of different MPA metabolites (M-1-M-5) in different species

MPA (100 μM) was incubated with liver microsomes (0.3 mg/ml) for 10 min. The rates of formation are expressed in picomoles per milligram per minute. Results represent the average of duplicate incubations.


Metabolite

M-1

M-2

M-3

M-4

M-5
tR (min) 13.4 18.7 20.1 22.1 23.4
tR (%) 51 71 76 84 89
Mol wt. 418 402 402 402 384
HLMs 54 391 172 227 52
PLMs 33 264 168 218 63
RLMs
51
321
86
300
28