P450s | P450 Isoform-Specific Reactions | M-2 | M-3 | M-4 |
---|---|---|---|---|
CYP1Aa | Phenacetin O-deethylation | 0.62 | 0.61 | 0.61 |
CYP2A6a | Coumarin 7-hydroxylation | 0.82 | 0.82 | 0.83 |
CYP2C8a | Paclitaxel 6α-hydroxylation | 0.82 | 0.83 | 0.83 |
CYP2C9 | Diclofenac 4′-hydroxylation | −0.11 | −0.11 | −0.08 |
CYP2C19 | S-Mephenytoin 4′-hydroxylation | 0.14 | 0.14 | 0.13 |
CYP2D6 | Dextromethorphan O-demethylation | 0.31 | 0.32 | 0.35 |
CYP2E1 | Chlorzoxazone 6-hydroxylation | 0.37 | 0.39 | 0.42 |
CYP3A4 | Testosterone 6β-hydroxylation | 0.97 | 0.98 | 0.98 |
CYP3A4 | Paclitaxel 3′-p-hydroxylation | 0.99 | 0.99 | 0.98 |
↵ a No metabolite formation was observed by recombinant CYP1A2, CYP2A6, and CYP2C8.