TABLE 1

Substrate concentration in micromolar used for microsomal incubations


N-Demethylation to MDA

Demethylenation to DHMA
CYP1A2
CYP2B6
CYP2C19
CYP2D6
CYP1A2
CYP3A4
CYP2C19
CYP2D6
R,S-MDMA
R-/S-MDMA
R,S-MDMA
R-/S-MDMA
R,S-MDMA
R-/S-MDMA
R,S-MDMA
R-/S-MDMA
R,S-MDMA
R-/S-MDMA
R,S-MDMA
R-/S-MDMA
R,S-MDMA
R-/S-MDMA
R,S-MDMA
R-/S-MDMA
10 10 10 5 10 5 0.5 0.5 5 5 5 5 1 1 0.08 0.08
40 40 20 10 15 10 2 2 12.5 10 10 10 2.5 2.5 0.15 0.15
100 100 40 20 40 40 7.5 7.5 25 25 25 25 5 5 0.23 0.23
300 200 70 40 70 75 10 10 37.5 50 50 50 10 10 0.38 0.38
500 300 200 75 100 100 40 40 50 75 100 100 25 25 0.5 0.5
750 500 300 125 200 250 100 100 123 100 250 250 50 75 2.5 2.5
1000 750 500 250 500 300 300 200 187.5 250 375 375 100 250 5 5
1250 1000 750 500 750 500 500 300 250 350 500 500 250 300 12.5 12.5
1500 1500 1000 750 1500 750 1000 500 375 500 750 750 500 500 25 50
2000 3000 1500 1000 2000 1000 1500 1000 500 750 1000 1000 1000 750 50 100
125 250














250
500