TABLE 2

Unbound fractions of the inducers in human plasma and hepatocytes

Data are mean values in triplicate (S.D.).


Inducer

Plasma

Hepatocytes
Conc.
fu, p
Conc.
fu, hept
μM μM
BST 1,10 0.0074 (0.003) 1 0.189 (0.010)
CMZ 1,10 0.041 (0.002) 20 0.520 (0.021)
DEX 1,10 0.300 (0.011) 100 0.589 (0.043)
EFA 1,10 0.029 (0.004) 5 0.063 (0.006)
PB 1,10 0.700 (0.092) 250 1.000 (0.074)
RIF
1,10
0.175 (0.011)
1
0.419 (0.052)