F2 values and -fold induction at highest concentration tested (given in parenthesis) for induction of CYP2C8, CYP2C9, and CYP2C19 mRNA in HepaRG cells treated with rifampicin F2 is the concentration resulting in a 2-fold increase of baseline mRNA levels. Values are mean ± S.D. of three separate batches of differentiated HepaRG cells.
F2 | -Fold Induction at Highest Concentration Tested (4 μM) | |
|---|---|---|
| CYP2C8 mRNA | 0.21 ± 0.03a | 2.9 ± 0.58 |
| CYP2C9 mRNA | 0.25 ± 0.03 | 2.3 ± 1.4 |
| CYP2C19 mRNA | 0.41 ± 0.25 | 2.9 ± 2.1 |
↵ a μM