TABLE 4

Papp in PAMPA and A > B Papp values in MDCK assays for 7 non-CNS drugs Data are presented as mean ± S.D.


Compound

PAMPA Retention Factor (Rf)

PAMPA Papp

A > B Papp in MDCK
× 10-6 cm/s × 10-6 cm/s
Loperamide 0.8 ± 0.02 7.8 ± 0.66 2.7 ± 1.07
Loratadine 1.0 ± 0.01 5.0 ± 1.35 8.9 ± 3.70
Prazosin 0.4 ± 0.10 9.9 ± 0.53 10.6 ± 1.67
Prednisone 0.3 ± 0.03 11.2 ± 0.42 12.3 ± 1.83
Quinidine 0.4 ± 0.04 12.9 ± 1.65 8.0 ± 1.91
Ritonavir N.D. N.D. 5.6 ± 0.58
Verapamil
0.6 ± 0.01
11.5 ± 0.60
12.6 ± 1.83
  • N.D., no data were generated.