TABLE 5

Dose recovered after dermal administration of Bmim-Cl (5 mg/kg) in a series of vehicles to male F-344 rats

Data are presented as mean ± S.D.; n = 3: DMF-water and ethanol (EtOH)-water; n = 4: water. Tissues (blood, liver, and kidneys) were collected at 48 or 72 h after administration.



Dose Recovered

DMF-H2O (48 h)
Ethanol-H2O (48 h)
H2O (72 h)
%
Feces 0.5 ± 0.0 0.8 ± 1.1 0.3 ± 0.4
Urine 12.3 ± 1.8 2.4 ± 1.4 1.1 ± 1.1
Tissues 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0
Application site skin 18.9 ± 2.9 14.6 ± 3.5 28.2 ± 9.0
Application site skin (washes and strips) 54.3 ± 6.8 71.4 ± 3.5 57.3 ± 6.3
Naïve site skin 0.1 ± 0.0 0.1 ± 0.0 0.1 ± 0.1
Trap 3.5 ± 2.9 8.8 ± 7.0 5.4 ± 3.3
Total recovery
89.5 ± 11.7
98.1 ± 9.7
92.4 ± 5.1