Metabolite | Metabolite Radioactivity Distribution | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BDC Rat (0-48 h) | Intact Rat (0-48 h) | Intact Dog (0-48 h) | BDC Dog (0-48 h) | ||||||||||||||||
Urine | Bile | Feces | Urine | Feces | Urine | Feces | Urine | Bile | Feces | ||||||||||
% of dose | |||||||||||||||||||
M1 | 3.3 | 18.1 | 4.3 | 0.48 | 63.4 | 0.85 | 11.3 | 2.2 | 7.4 | 10.3 | |||||||||
M2 | 0.33 | 2.1 | ND | 0.03 | 0.05 | 0.35 | 2.3 | 1.4 | 1.3 | 0.25 | |||||||||
M3 | ND | ND | ND | ND | ND | 0.30 | ND | 0.7 | 1.3 | ND | |||||||||
M4 | 1.3 | 4.1 | 0.54 | 0.48 | ND | 0.60 | 1.5 | 2.3 | 8.3 | 1.1 | |||||||||
M5 | 0.99 | 2.4 | ND | 0.03 | 7.0 | 0.20 | 3.8 | 1.3 | 2.2 | 1.5 | |||||||||
M7 | ND | ND | 0.9 | ND | 0.88 | 0.15 | 1.5 | 0.4 | 2.2 | 0.25 | |||||||||
M10 | ND | 0.34 | ND | ND | ND | ND | 0.75 | 0.14 | 5.3 | 0.25 | |||||||||
M11 | ND | ND | 0.05 | ND | ND | ND | ND | 0.14 | 3.1 | 0.25 | |||||||||
M12 | ND | 1.0 | 0.10 | 0.03 | 3.5 | ND | 1.5 | 0.28 | 0.44 | 1.3 | |||||||||
M13 | 0.11 | 0.10 | ND | ND | ND | 0.10 | ND | 0.68 | 0.44 | ND | |||||||||
M14 | ND | ND | ND | 0.10 | ND | 0.10 | ND | 0.41 | ND | ND | |||||||||
Parent | 3.8 | 2.0 | 9.6 | 2.1 | 7.0 | 2.0 | 46.8 | 2.8 | 6.6 | 7.5 | |||||||||
Othersa | 1.2 | 4.1 | 2.7 | 0.1 | 6.3 | 0.30 | 6.0 | 0.85 | 5.3 | 2.3 | |||||||||
Total | 11.0 | 34.2 | 18.1 | 3.4 | 88.1 | 5.0 | 75.5 | 13.6 | 43.9 | 25.0 |
ND, not detected.
↵a Radioactivity distributed among many small peaks, each representing <0.03%. M15 was a trace metabolite and detected by LC/MS in dog bile.