Metabolite pattern in plasma, urine, and feces after p.o. administration of 200 mg of [14C]dabigatran etexilate in healthy volunteers
Data are mean percentage recovery from five individuals.
Metabolite | Synthetic Reference | Plasma (2, 4, and 6 h) | Urine (0-48 h) | Feces (main fractions) |
|---|---|---|---|---|
| M354 | Trace amountsa | |||
| M369 | 0.5% | 0.4% | ||
| M324 | BIBR1151 | Trace amountsa | 0.4% | 2.3% |
| M355 | BI00003521 | Trace amountsa | 0.6% | 0.6% |
| M325 | CD00000338 | 0.3% | ||
| M396 | BI00003522 | Trace amountsa | 0.1% | 0.1% |
| M500(1) | Trace amountsa | Trace amountsa | ||
| M531 | Trace amountsa | |||
| M574 | Trace amountsa | |||
| M472 | Dabigatran | 100.0% | 4.3% | 66.1% |
| M648 + M690 | Trace amountsa,b | 0.4% | ||
| M602 | 0.5% | |||
| M636 | <0.1% | |||
| M630 | 0.1% | 0.2% | ||
| M488 | Trace amountsa | 0.1% | 1.2% | |
| M614 | Trace amountsa | Trace amountsa | ||
| M400 | BI00003543 | 0.2% | 5.8% | |
| M616 | <0.1% | 2.0% | ||
| M600 | BIBR1087 | Trace amountsa | 0.2% | |
| M628 | Dabigatran etexilate | Trace amountsa | ||
| Subtotal |
| 100.0% | 7.1% | 79.4% |