Predicted change in AUCI/AUC for compounds exhibiting Ki < 1 μM for (S)-mephenytoin
Inhibitor | Predicted AUCI/AUC | Actual DDIa | ||||
|---|---|---|---|---|---|---|
| (S)-Mephenytoin | (S)-Omeprazole | (R)-Omeprazole | ||||
| Loratadine | 1.8 | 1.2 | 1.2 | |||
| Fluvoxamine | 13.8 | 5.3 | 6.6 | 5.6b | ||
| Ticlopidinec | 9.4 | 3.1 | 3.7 | 2.4d | ||
| Clotrimazole | 1.0 | 1.0 | 1.0 | |||
| (R)-Fluoxetinec | 3.8 | 1.3 | 1.3 | |||
| Sertraline | 1.9 | 1.1 | 1.2 | |||
| Oxybutynin | 1.1 | 1.0 | 1.1 | |||
| Ketoconazole | 1.3 | 1.2 | 1.1 | |||
| Raloxifene | 1.4 | 1.2 | 1.3 | |||
| Ethynylestradiol | 1.0 | 1.0 | 1.0 | |||
| (R)-Omeprazole | 1.1 | 1.0 | 1.0 | |||
| (S)-Omeprazole | 1.4 | 1.1 | 1.1 | |||
| Nifedipine | 1.1 | 1.0 | 1.0 | |||
| (S)-Fluoxetinec | 1.3 | 1.0 | 1.1 |
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