TABLE 1

Pharmacokinetic data of silibinin in plasma and bile of rats after a dose of 10 mg/kg



Silibinin Alone

Unconjugated
Total
Plasma
   AUC (min · mg/ml) 0.16 ± 0.03 3.11 ± 0.81
   t½ (min) 31 ± 5.1 94 ± 14
   Cmax (μg/ml) 28 ± 8 37 ± 15
   Cl (ml/kg/min) 70 ± 11.5 3.8 ± 1.1
Bile
   AUC (min · mg/ml) 0.2 ± 0.03 127 ± 16
   t½ (min) 7.6 ± 0.4 72 ± 10
   Cmax (μg/ml) 33 ± 2.9 3632 ± 373
   Tmax (min) 1 ± 0 6.3 ± 1.1
   AUCbile/AUCblood
1.3 ± 0.3
41 ± 7.3