TABLE 1

Experimental conditions for the selected compounds with details on the internal standards, mass transitions, and retention times


Compound

Internal Standard

Electrospray Ionization

Transition

Retention Time
min
α-Naphthoflavone Triazolam Positive 273.1 > 115.3 4.9
Buprenorphine Mibefradil Positive 468.5 > 396.3 2.7
Buspirone Quinidine Positive 386.4 > 122.2 3.6
Carvedilol Buspirone Positive 407.4 > 100.4 4.2
Codeine Levallorphan Positive 300.2 > 215.1 3.4
Desipramine Zidovudine Positive 267.0 > 72.30 3.7
Dextromethorphan Quinidine Positive 272.2 > 171.4 3.4
Diclofenac Tolbutamide Negative 293.9 > 250.1 4.6
Emodin Diclofenac Negative 269.3 > 225.3 3.0
Felodipine Nifedipine Positive 384.3 > 338.1 3.3
Gemfibrozil Tolbutamide Negative 249.2 > 121.2 4.5
Imipramine Desipramine Positive 281.2 > 86.50 3.7
Indinavir Dextromethorphan Positive 614.6 > 421.3 2.9
Levallorphan Codeine Positive 284.3 > 157.4 4.5
Mibefradil Verapamil Positive 496.3 > 202.2 3.8
Midazolam Diazepam Positive 326.0 > 291.3 4.4
Mycophenolic acid Warfarin Negative 319.4 > 191.2 4.0
Naloxone Levallorphan Positive 328.4 > 310.3 3.0
Nifedipine Felodipine Positive 347.3 > 315.4 2.7
Oxazepam Midazolam Positive 286.9 > 241.3 4.0
Quinidine Dextromethorphan Positive 325.1 > 307.3 3.0
Raloxifene Terfenadine Positive 474.4 > 112.3 3.3
Repaglinide Indomethacin Positive 453.3 > 230.1 4.3
Ritonavir Dextromethorphan Positive 743.4 > 573.2 2.6
Rosiglitazone Buspirone Positive 358.3 > 135.3 4.2
Saquinavir Terfenadine Positive 671.2 > 570.4 3.7
Simvastatin Terfenadine Positive 441.4 > 325.4 4.0
Tacrolimus Verapamil Positive 821.7 > 768.4 3.1
Tamoxifen Verapamil Positive 372.3 > 72.50 3.5
Terfenadine Metoprolol Positive 482.3 > 436.2 4.5
Triazolam Diazepam Positive 343.0 > 308.3 3.8
Troglitazone Diltiazem Positive 442.4 > 165.4 3.3
Verapamil Mibefradil Positive 455.4 > 165.4 3.3
Zidovudine
Desipramine
Positive
268.3 > 127.3
2.4