Pharmacokinetic data of 50 mg/kg silibinin alone (control group) and with DMN (liver cirrhosis group) in rat plasma and bile Data are expressed as means ± S.E.M. (n = 6).
Control Group | Liver Cirrhosis Group | |||||
|---|---|---|---|---|---|---|
| Unconjugated | Total | Unconjugated | Total | |||
| Plasma | ||||||
| AUC (min mg/ml) | 1.3 ± 0.2 | 29 ± 1.2 | 0.7 ± 0.04* | 53 ± 11* | ||
| t½ (min) | 39 ± 3.8 | 157 ± 13 | 52 ± 10 | 320 ± 62* | ||
| Cmax (μg/ml) | 143 ± 35 | 133 ± 9.8 | 83 ± 12 | 145 ± 6.2 | ||
| Cl (ml/kg/min) | 50 ± 5.5 | 1.73 ± 0.2 | 76 ± 5.3 | 1.07 ± 0.3 | ||
| Bile | ||||||
| AUC (min mg/ml) | 6 ± 0.4 | 1302 ± 91 | 5.5 ± 1.3 | 1040 ± 126 | ||
| t½ (min) | 10 ± 0.8 | 90 ± 7.3 | 21 ± 1.7* | 229 ± 77* | ||
| Cmax (μg/ml) | 429 ± 41 | 10863 ± 509 | 350 ± 47 | 6562 ± 872* | ||
| Tmax (min) | 2.3 ± 1.1 | 22.5 ± 4.7 | 3.7 ± 1.1 | 35 ± 3.9* | ||
| AUCbile/AUCblood | 4.9 ± 1.4 | 45 ± 4.4 | 8.5 ± 2.1* | 21.6 ± 6.7* | ||
↵* P < 0.05, significantly different from the 50 mg/kg silibinin control group