TABLE 3

Pharmacokinetic data of 50 mg/kg silibinin alone (control group) and with DMN (liver cirrhosis group) in rat plasma and bile Data are expressed as means ± S.E.M. (n = 6).



Control Group

Liver Cirrhosis Group

Unconjugated
Total
Unconjugated
Total
Plasma
   AUC (min mg/ml) 1.3 ± 0.2 29 ± 1.2 0.7 ± 0.04* 53 ± 11*
   t½ (min) 39 ± 3.8 157 ± 13 52 ± 10 320 ± 62*
   Cmax (μg/ml) 143 ± 35 133 ± 9.8 83 ± 12 145 ± 6.2
   Cl (ml/kg/min) 50 ± 5.5 1.73 ± 0.2 76 ± 5.3 1.07 ± 0.3
Bile
   AUC (min mg/ml) 6 ± 0.4 1302 ± 91 5.5 ± 1.3 1040 ± 126
   t½ (min) 10 ± 0.8 90 ± 7.3 21 ± 1.7* 229 ± 77*
   Cmax (μg/ml) 429 ± 41 10863 ± 509 350 ± 47 6562 ± 872*
   Tmax (min) 2.3 ± 1.1 22.5 ± 4.7 3.7 ± 1.1 35 ± 3.9*
   AUCbile/AUCblood
4.9 ± 1.4
45 ± 4.4
8.5 ± 2.1*
21.6 ± 6.7*
  • * P < 0.05, significantly different from the 50 mg/kg silibinin control group