Pharmacokinetic parameters of famotidine in sham-operated and I/R rats
Each value represents the mean ± S.D. from six rats.
| Sham | I/R | |
|---|---|---|
| Dose excreted in urine (%) | 67.3 ± 7.5 | 18.1 ± 14.6*** |
| AUC (μg · min/ml) | 911 ± 94 | 1925 ± 406*** |
| V1 (ml/kg) | 428 ± 157 | 424 ± 109 |
| Vss (ml/kg) | 801 ± 168 | 810 ± 223 |
| CLtot (ml/min/kg) | 22.1 ± 2.3 | 10.7 ± 2.0*** |
| CLren (ml/min/kg) | 14.9 ± 2.4 | 2.1 ± 1.8*** |
| kel (min-1) | 0.058 ± 0.021 | 0.026 ± 0.007*** |
| t1/2α (min) | 6.7 ± 3.2 | 7.0 ± 4.2 |
| t1/2β (min) | 38.8 ± 13.2 | 64.0 ± 19.7* |