TABLE 2

Inhibition of human ABC transporters by lapatinib

Data are the means (± S.D.) from triplicate wells.

Transporter IC50 Substrate
μM
Pgp 3.9 (0.6) [3H]Digoxin
BCRP 0.025 (0.003) [3H]Cimetidine
OATP1B1 4.0 (2.1) [3H]Estradiol 17β-d-glucuronide