Inhibition of human solute carriers by 30 μM lapatinib
Data are the mean (± S.D.) from triplicate wells from a single concentration screening experiment.
| Transporter | Control Activity | Substrate |
|---|---|---|
| % | ||
| OAT 1 | 78.7 (2.2) | [14C]p-Aminohippuric acid |
| OAT 2 | 86.4 (2.1) | [3H]Prostaglandin F2α |
| OAT 3 | 40.2 (0.3) | [3H]Estrone sulfate |
| OAT 4 | 119 (3.5) | [3H]Estrone sulfate |
| OCT 1 | 62.1 (1.1) | [14C]Tetraethylammonium |
| OCT 2 | 88.4 (4.6) | [14C]Tetraethylammonium |
| OCT 2A | 70.3 (3.5) | [14C]Tetraethylammonium |
| OCT 3 | 113 (4.2) | [3H]Histamine |
| URAT1 | 79.8 (2.1) | [14C]Uric acid |