TABLE 4

Mean tissue concentrations and tissue/blood ratios of radioactivity in male rats after a single oral administration of 10 mg/kg [14C]lapatinib

Tissue Concentration Tissue/Blood Ratio
0.5 h 4 h 8 h 24 h 0.5 h 4 h 8 h 24 h
μg equivalents/g tissue
Blood 0.26 0.92 0.31 BLQ 1.00 1.00 1.00 NC
Brain BQL 0.09 0.04 BQL NC 0.10 0.13 NC
Cerebrospinal fluid 0.03 0.36 0.29 BQL 0.12 0.39 0.94 NC
Harderian gland 0.08 1.22 1.15 0.62 0.31 1.33 3.71 NC
Heart 0.21 1.13 0.54 BQL 0.77 1.23 1.74 NC
Kidney 0.71 3.40 1.77 0.16 2.73 3.70 5.71 NC
Liver 1.51 5.55 2.47 0.22 5.81 6.03 7.97 NC
Muscle 0.03 0.46 0.26 BQL 0.12 0.50 0.84 NC
  • BLQ, below limit of quantification; NC, not calculated.