Predose Treatment | AUC(0-all) | Cmax | Tmax | t1/2 |
---|---|---|---|---|
ng · h/ml | ng/m | h | ||
Vehicle | 2094 (644) | 725 (227) | 0.88 [0.5-1.0] | 1.08 (0.06) |
GF120918 (50 mg/kg)a | 2152 (1405) | 533 (493) | 0.75 [0.5-1.0] | 2.78 (1.14) |
↵ a GF120918 treatment consisted of a single oral 50 mg/kg dose given 2 h before lapatinib dosing.