TABLE 5

Pharmacokinetic parameters of lapatinib after a single oral dose of 10 mg/kg to male rats 2 h after pretreatment with a single oral dose of vehicle or 50 mg/kg GF120918

Data are the means (± S.D.) from four male animals, except for Tmax, which represents the range.

Predose Treatment AUC(0-all)CmaxTmaxt1/2
ng · h/ml ng/m h
Vehicle 2094 (644) 725 (227) 0.88 [0.5-1.0] 1.08 (0.06)
GF120918 (50 mg/kg)a 2152 (1405) 533 (493) 0.75 [0.5-1.0] 2.78 (1.14)
  • a GF120918 treatment consisted of a single oral 50 mg/kg dose given 2 h before lapatinib dosing.