Enzyme Source | Parameter | No Albumin | BSA | HSA-FAF | HSA |
---|---|---|---|---|---|
HLM | K m | 20.8 ± 1.5 | 4.7 ± 0.3* | 4.7 ± 0.2* | 26.5 ± 1.0* |
V max | 17.8 ± 0.3 | 20.2 ± 0.5* | 20.7 ± 0.8* | 17.4 ± 0.3 | |
CLint | 0.86 ± 0.05 | 4.3 ± 0.3* | 4.5 ± 0.1* | 0.66 ± 0.02* | |
CLint.liver | 2.93 ± 0.16 | 14.85 ± 0.87* | 15.39 ± 0.32* | 2.25 ± 0.07* | |
CYP2C9 | K m | 14.4 ± 1.3 | 3.6 ± 0.2* | 4.1 ± 0.2* | 14.7 ± 0.1 |
V max | 0.230 ± 0.006 | 0.246 ± 0.001* | 0.249 ± 0.004* | 0.236 ± 0.003 | |
CLint | 1.17 ± 0.07 | 4.99 ± 0.22* | 4.49 ± 0.13* | 1.17 ± 0.02 | |
| CLint.liver | 4.01 ± 0.24 | 17.06 ± 0.75* | 15.36 ± 0.43* | 3.99 ± 0.06 |
↵* Significantly different (p < 0.05) from control value (determined in the absence of albumin)