P450 amount in the main intestinal section of female rat
Results from three females rats in each case are expressed as means ± S.D. The percentage shown in parentheses refers to the relative contribution of the given P450 to the sum of P450 amount in the respective segment.
Duodenum | Upper Jejunum | Middle Jejunum | Lower Jejunum | Ileum | Colon | ||
|---|---|---|---|---|---|---|---|
| fmol/mg protein | |||||||
| CYP2B1 | 107 ± 62 (30) | 645 ± 252 (67) | 333 ± 80 (59) | 98 ± 75 (31) | |||
| CYP3A | 176 ± 56 (49) | 243 ± 44 (25) | 187 ± 39 (33) | 160 ± 23 (51) | |||
| CYP2D1 | 70 ± 25 (20) | 71 ± 17 (8) | 43 ± 5 (8) | 55 ± 29 (17) | 44 ± 9 (85) | 58 ± 6 (91) | |
| CYP2C6 | 3 ± 1 (1) | 3 ± 1 (<1) | 3 ± 1 (1) | 4 ± 2 (1) | 8 ± 5 (15) | 6 ± 5 (9) | |
| Sum of P450s | 356 ± 144 | 962 ± 314 | 566 ± 125 | 317 ± 129 | 52 ± 14 | 64 ± 11 | |