TABLE 1

Pharmacokinetic parameters of β-lactam antibiotics in rats




Mol. Wt.

Dosea

CLtotal

Xbile

Xurine

CLbile, plasma

CLbile, liver

CLurine, kidneyb

References
mg/kg ml/min/kg % dose ml/min/kg
Cefoperazone 645 20 20.1 80.9 12.1 16.3 10.1c 0.0d This study
Cefbuperazone 627 20 28.0 80.0 19.3 22.4 7.5e 0.3d Jpn J Antibiot35:2163-2173, 1982 (in Japanese)
Cefpiramide 612 20 9.5 59.6 35.2 5.7 5.8e 0.3f Chemotherapy22 (Suppl 1):213-217, 1982 (in Japanese)
Chemotherapy31 (Suppl 1):114-123, 1983 (in Japanese)
Cefotetan 576 20 12.8 48.1 51.9 6.2 9.6e 1.8f Chemotherapy30 (Suppl 1):106-117, 1982 (in Japanese)
Agents Chemother20:176-183, 1981
Ceftriaxone 554 20 4.0 61.8 32.0 2.5 8.2c 0.0d Chemotherapy32 (Suppl 7):136-147, 1984 (in Japanese)
Antimicrob Agents Chemother26:204-207, 1984
Cefotiam 525 20 25.1 35.7 55.6 9.0 4.6c 1.0d Chemother27 (Suppl 3):121-131, 1979 (in Japanese)
Antimicrob Agents Chemother17:157-164, 1980
Cefmetazole 471 20 34.5 66.9 19.8 23.1 8.1e 1.6f Chemotherapy30 (Suppl 1):106-117, 1982 (in Japanese)
Cefamandole 462 20 17.0 29.6 57.2 5.0 4.9e 2.9f Chemotherpy27 (Suppl 5):112-119, 1979 (in Japanese)
Antimicrob Agents Chemother17:157-164, 1980
Cefazolin 454 20 7.8 18.0 67.6 1.4 3.2e 3.0f Chemotherapy30 (Suppl 1):106-117, 1982 (in Japanese)
Cefixime 453 100 3.2 30.2 74.5 1.0 2.5c 0.5d Chemotherapy33 (Suppl 6):157-167, 1985 (in Japanese)
Ceftezole 440 20 8.2 5.5 74.3 0.5 1.2e 3.2f J Antibiot29:1071-1082, 1976
Antimicrob Agents Chemother10:1-13, 1976
Cefuroxime 424 25 9.9 17.1 82.9 1.7 2.1e 2.8f Chemotherapy27 (Suppl 6):104-110, 1970 (in Japanese)
Cefdinir 395 20 8.4 3.4 80.0 0.3 1.1c 1.9d Chemotherapy33 (Suppl 6): 157-167, 1988 (in Japanese)
Cephalexin
347
20
12.4
9.3
74.0
1.2
0.2c
0.8d
Chemotherapy33 (Suppl 6): 157-167, 1985 (in Japanese)
  • a Intravenous administration, except for cefotiam, which was administered i.m.

  • b Glomerular filtration rate (GFR) was assumed to be 5.24 ml/min/kg.

  • c Calculated as Xbile/(Kp, liver × AUC), where Kp, liver was the mean value for two to four sampling points.

  • d Calculated as (Xurinefp GFR · AUC)/(Kp, kidney × AUC), where Kp, kidney was the mean value for two to four sampling points.

  • e Calculated as Xbile/AUCliver.

  • f Calculated as (Xurinefp GFR · AUC)/AUCkidney.