Pharmacokinetic parameters of cefoperazone and cephalexin in SDR and EHBRs
Cefoperazone | Cephalexin | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CLtotal | MRT | CLbile, plasma | CLtotal | MRT | CLbile, plasma | |||||
| ml/min/kg | min | ml/min/kg | ml/min/kg | min | ml/min/kg | |||||
| SDR | 20.1 ± 2.8 | 14.2 ± 1.7 | 16.3 ± 2.6 | 12.4 ± 2.1 | 31.9 ± 4.0 | 1.15 ± 0.24 | ||||
| EHBR | 6.02 ± 0.71* | 45.6 ± 6.8* | 1.65 ± 0.41* | 10.6 ± 0.3 | 42.0 ± 3.1 | 0.156 ± 0.022* | ||||
↵* Significantly different from SDRs (p < 0.05).