TABLE 1

Correlation (r) between induction of CYP3A4 and MDR1 transcripts by RTV, NFV, or RIF and PXR activation and induction of CYP3A4 or MDR1 by various PIs and rifampin


Induction

PXR Activation and Induction
mRNA
RIF 3A4
RTV 3A4
mRNA/Activation
MDR1
PXR
RTV CYP3A4 0.88 0.93
    3A4 0.8
    MDR1 0.91
NFV MDR1 0.93
    3A4 0.86 0.83
    MDR1
0.91
0.92