TABLE 2

Determination of P450 CLint of individual human P450s to oxidative metabolism


Compound

CYP1A2

CYP2B6

CYP2C8

CYP2C9

CYP2C19

CYP2D6

CYP3A4

CYP3A5
CLint (μl/min/pmol)
Desipramine N.D. N.D. N.D. N.D. 0.19 ± 0.09 7.28 ± 1.28 N.D. 0.01 ± 0.01
Imipramine 0.04 ± 0.01 N.D. 0.05 ± 0.02 N.D. 2.53 ± 1.13 5.79 ± 0.53 0.05 ± 0.01 0.02 ± 0.02
Tolterodine N.D. 0.02 ± 0.01 0.40 ± 0.03 N.D. 0.85 ± 0.22 10.22 ± 1.93 N.D. 0.12 ± 0.02
Propranolol 0.14 ± 0.04 N.D. 0.01 ± 0.01 N.D. 0.71 ± 0.24 4.48 ± 0.44 N.D. N.D.
Metoprolol
N.D.
N.D.
N.D.
N.D.
N.D.
1.02
N.D.
N.D.
  • N.D., not detectable (<0.01 μl/min/pmol). Mean ± S.D. for n = 3 separate experiments.