Estimation of fraction metabolized by individual major human hepatic P450s
The fraction metabolized by P450s in human liver is estimated by accounting for the mean fraction abundance of each individual P450 human liver as determined by Rowland Yeo et al. (2004) (CYP1A2 0.11, CYP2B6 0.07, CYP2C8 0.07, CYP2C9 0.17, CYP2C19 0.026, CYP2D6 0.02, CYP3A4 0.38, and CYP3A5 0.03).
Compound | CYP1A2 | CYP2B6 | CYP2C8 | CYP2C9 | CYP2C19 | CYP2D6 | CYP3A4 | CYP3A5 |
|---|---|---|---|---|---|---|---|---|
| Desipramine | 0.03 | 0.97 | ||||||
| Imipramine | 0.02 | 0.31 | 0.55 | 0.09 | ||||
| Tolterodine | 0.01 | 0.11 | 0.08 | 0.79 | 0.01 | |||
| Propranolol | 0.12 | 0.15 | 0.73 | |||||
| Metoprolol |
|
|
|
|
| 1.00 |
|
|