TABLE 1
Clinical drug-drug interactions with ketoconazole
Druga | Reported -Fold AUC Change | Commercial Availabilityb | Significant in Vitro Metabolic Clearancec |
|---|---|---|---|
| Alfuzosin | 3.20 | ||
| Alprazolam | 3.98 |
| |
| Aprepitant | 5.00 | ||
| Artemether | 2.31 | ||
| Bosentan | 2.22 | ||
| Budesonide | 3.96–6.81 |
|
|
| Buprenorphine | 2.30 |
|
|
| Cyclosporine | 4.39 |
| |
| Docetaxel | 2.22 |
|
|
| Eletriptan | 5.90 | ||
| Eplerenone | 5.40 | ||
| Irinotecan | 2.09 |
| |
| Levomethadyl | 5.53 | ||
| Loratadine | 3.47 |
|
|
| Methylprednisolone | 2.36 |
|
|
| Midazolam | 15.9 |
| |
| Nisoldipine | 25.3 | ||
| Omeprazole | 2.05 |
| |
| Saquinavir | 2.90 | ||
| Sirolimus | 10.9 |
|
|
| Tacrolimus | 2.39 |
|
|
| Tretinoin | 1.72 |
| |
| Tadalafil | 4.07 | ||
| Tirilazad | 4.09 | ||
| Tolterodine | 2.58 | ||
| Triazolam | 22.4 |
| |
| Vardenafil | 10.0 | ||
| Zolpidem | 1.67 |
|
|
-
↵ a Data from University of Washington DDI database handout (2004, http://www.duginteractioninfo.org)
-
↵ b Available from Sigma-Aldrich
-
↵ c Compounds were not in our previous study and had <60% remaining at the end of 15 min, 0.5 mg/ml microsomal incubation