TABLE 3

Pharmacodynamic parameter estimates of PF02341066 for tumor growth inhibition in athymic mice bearing GTL16 or U87MG tumors after repeated oral administration of PF02341066 Precision of the estimates is expressed as S.E. in parentheses.


Parameters

GTL 16 Tumor Xenografts

U87MG Tumor Xenografts
EC50 (ng/ml) 213 (123) 94.1 (52.3)
E max 1 fixed 1 fixed
kin (h–1) 0.0130 (0.00214) 0.0134 (0.00136)
kout (h–1) 0.00672 (0.00243) 0.00236 (0.00137)
OFV
2404
2514
  • EC50, the concentration causing one-half maximum effect; Emax, maximum effect; kin, the tumor growth rate constant; kout, the tumor loss rate constant; OFV, the objective function value