Inhibitor | Total Clinical Plasma Cmaxa | fu | Unbound Clinical Plasma Cmax | Estimated Human Liver Concentrationb | Ki |
---|---|---|---|---|---|
μM | μM | μM | μM | ||
Bupropion | 0.67 | 0.16c | 0.11 | 0.605–1.03 | 21 |
Hydroxybupropion | 4.01 | 0.23a | 0.92 | 5.06–8.65 | 13.3 |
Threohydrobupropion | 2.34 | 0.58a | 1.35 | 7.43–12.7 | 5.4 |
Erythrohydrobupropion | 0.43 | 0.58a | 0.25 | 1.38–2.35 | 1.7 |