Danshen Components | IC50 | ||||||||
---|---|---|---|---|---|---|---|---|---|
CYP1A2 | CYP2C9 | CYP2D6 | CYP3A4a | CYP3A4b | |||||
μM | |||||||||
Hydrophilic components | |||||||||
Protocatechuic acid | >200 | >200 | >200 | >200 | >200 | ||||
Protocatechuic aldehyde | >200 | >200 | >200 | 130 | 160 | ||||
Danshensu | 110 | 50 | >200 | >200 | >200 | ||||
Salvianolic acid B | 105 | >200 | >200 | >200 | >200 | ||||
Lipophilic components | |||||||||
Tanshinone I | 0.75 | >200 | 120 | >200 | >200 | ||||
Tanshinone IIA | 1.3 | >200 | >200 | >200 | >200 | ||||
Cryptotanshinone | 0.75 | 33 | 75 | >200 | >200 | ||||
Positive controlc | 0.63 | 0.3 | 0.12 | 0.05 | 0.045 |