The IC50 values for the inhibition of danshen components on CYP enzymes activities
Danshen Components | IC50 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| CYP1A2 | CYP2C9 | CYP2D6 | CYP3A4a | CYP3A4b | |||||
| μM | |||||||||
| Hydrophilic components | |||||||||
| Protocatechuic acid | >200 | >200 | >200 | >200 | >200 | ||||
| Protocatechuic aldehyde | >200 | >200 | >200 | 130 | 160 | ||||
| Danshensu | 110 | 50 | >200 | >200 | >200 | ||||
| Salvianolic acid B | 105 | >200 | >200 | >200 | >200 | ||||
| Lipophilic components | |||||||||
| Tanshinone I | 0.75 | >200 | 120 | >200 | >200 | ||||
| Tanshinone IIA | 1.3 | >200 | >200 | >200 | >200 | ||||
| Cryptotanshinone | 0.75 | 33 | 75 | >200 | >200 | ||||
| Positive controlc | 0.63 | 0.3 | 0.12 | 0.05 | 0.045 | ||||