TABLE 3

The Ki values and mode of inhibition of danshen components on P450 enzyme activities


Danshen Components

P450 Enzyme

Ki

Mode of Inhibition
μM
Danshensu CYP2C9 35 Competitive
Tanshinone I CYP1A2 0.48 Competitive
Tanshinone IIA CYP1A2 1.1 Competitive
Cryptotanshinone
CYP1A2, CYP2C9, CYP2D6
0.45, 8, 68
Competitive, mixed, mixed