In Vitro Abbreviations
Abbreviation | Definition | Measured | Model Fit | Predicted | Equation Number |
|---|---|---|---|---|---|
| X | Amount | √ | 1, 2, 4, 6 | ||
| C | Concentration | √ | 1, 2, 3, 4, 5, 6, 7 | ||
| V | Volume | √ | 5, 6, 7, 10, 11, 12, 13, 14 | ||
| med | Medium compartment of incubation | √ | 1, 2, 3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14, 15 | ||
| cell | Intracellular compartment of incubation | √ | 2, 3, 6, 7, 10, 11, 12, 14 | ||
| mem | Cell membrane compartment of incubation | √ | 4, 5, 6, 7, 10, 11, 12, 14 | ||
| hep | Hepatocyte (cell membrane + intracellular) | √ | Supplemental data | ||
| CLint,uptake | Unbound sinusoidal uptake intrinsic clearance | √ | 8–10, 12, 14 | ||
| CLint,efflux | Unbound sinusoidal efflux intrinsic clearance | √ | 8–10, 12, 14 | ||
| CLint,pass | Unbound passive diffusion intrinsic clearance | √ | 8–10, 12, 14 | ||
| CLint,met | Unbound metabolic intrinsic clearance. | √ | 8–10, 12, 14 | ||
| CLinc | Clearance from the whole incubation (Homogeneous sampling from incubation) | √ | √ | 10, 11, 13, 15 | |
| CLmed | Clearance from the medium compartment of the incubation | √ | √ | 1, 3, 8, 13, 15 | |
| CLhep | Clearance from the hepatocytes (cell membrane + intracellular) | √ | √ | Supplemental data | |
| fuinc | Fraction unbound in the incubation (only valid when no transport occurs) | √ | 6, 7 | ||
| fmed,ss | Fraction in the medium at steady-state | √ | 14, 15 | ||
| fucell | Unbound fraction within the intracellular compartment | √ | 7, 10–12, 14 | ||
| k mem | Proportionality constant between amount in cell membrane and concentration of medium | √ | 4–7, 10–12, 14 | ||
| Vssmed | Steady-state volume of distribution in medium | √ |
| √ | 12–14 |