Atorvastatin | Cerivastatin | Indomethacin* | |
---|---|---|---|
Bile duct cannulated | |||
Cl (ml/min/kg) | 43, 43 | 17 ± 6 | 0.2, 0.3 |
Plasma Css (ng/ml) | 370, 420 | 690 ± 270 | 4400, 3800 |
Liver Css (ng/g tissue) | 16,000, 26,000 | 39,000 ± 8000 | 920, 920 |
Liver/plasma ratio | 52, 62 | 65 ± 37 | 0.21, 0.24 |
Muscle Css (ng/g tissue) | 84, 210 | 270 ± 110 | 160, 170 |
Muscle plasma ratio | 0.2, 0.5 | 0.395 ± 0.001 | 0.036, 0.046 |
Biliary Cl (ml/min/kg) | 8.9, 7.1 | 0.4 ± 0.1 | 0.001, 0.001 |
Noncannulated | |||
Cl (ml/min/kg) | 47 ± 8 | 27 ± 11 | 0.51 ± 0.04 |
Vss (l/kg) | 0.5 ± 0.1 | 3.0 ± 1.9 | 0.19 ± 0.03 |
Half-life (h) | 1.2 ± 0.5 | 2.9 ± 0.4 | 4.6 ± 1.0 |
↵* Indomethacin was dosed to bile duct cannulated rats by bolus injection and tissue samples taken at 7 h