Predicted in vivo parameters for atorvastatin, cerivastatin, and indomethacin in the rat using a standard scaling method and a seven-compartment model
Atorvastatin | Cerivastatin | Indomethacin | |
|---|---|---|---|
| Standard scaling | |||
| Metabolic CL (ml/min/kg) | 12 | 5 | 0.9 |
| Seven-compartment model | |||
| Metabolic CL (ml/min/kg) | 24 | 8.4 | 0.18 |
| Vss (l/kg) | 1.4 | 1.3 | 0.14 |
| Plasma Css (ng/ml) | 670 | 1600 | 4400 |
| Liver Css (ng/g tissue) | 10,000 | 24,000 | 1400 |
| Liver/plasma ratio | 15 | 15 | 0.31 |
| Liver cell Css (ng/g tissue) | 16,000 | 38,000 | 680 |
| Liver free cell/plasma free ratio | 8.3 | 7.2 | 4.2 |
| Muscle Css (ng/g tissue) | 670 | 780 | 140 |
| Muscle/plasma ratio | 1.0 | 0.5 | 0.03 |
| Half-life (h) | 0.82 | 3.4 | 8.2 |