Ki values for zonampanel in OAT1-, OAT2-, and OAT3-mediated uptake of their prototypical substrates in rats and humans
Rat | Humana | |||||
|---|---|---|---|---|---|---|
| Substrate | Ki
b
| Substrate | Ki | |||
| μM | μM | |||||
| OAT1 | p-Aminohippuric acid | 7.02 ± 0.21 | p-Aminohippuric acid | 1.4 | ||
| OAT2 | Salicylic acid | 9.51 ± 2.24 | Prostaglandin F2α | >1000 | ||
| OAT3 | Estrone-3-sulfate | 10.4 ± 2.0 | Estrone-3-sulfate | 11.8 | ||
↵ a Cited from our previous study (Hashimoto et al., 2004)
↵ b Parameters were calculated from the data in Fig. 2 (estimate ± S.E.)