TABLE 3

Ki values for probenecid and cimetidine in OAT1-, OAT2-, and OAT3-mediated uptake of [14C]zonampanel in rats and humans



Ki
Probenecid
Cimetidine

Rata
Humanb
Rata
Humanb
μM
OAT1 1.44 ± 0.04 5.1 >1000 ND
OAT2 >1000 ND >1000 ND
OAT3
1.13 ± 0.12
2.6
8.74 ± 5.62
42.9