NMR data, 1H chemical shifts of dexmedetomidine, its N3- and N1-glucuronides, DG1 and DG2, respectively, and N3-glucuronide of levomedetomidine, LG1
Dexmedetomidine | DG1 | DG2 | LG1 | |
|---|---|---|---|---|
| H2 | 8.56 | 8.87 | 8.66 | 8.49 |
| H5 | 7.25 | 7.37 | 7.51 | 7.31 |
| H6 | 4.60 | 4.62 | 4.57 | 4.53 |
| H8(CH3) | 1.60 | 1.56 | 1.59 | 1.58 |
| H9 | 6.98 | 6.85 | 7.03 | 6.76 |
| H10 | 7.15 | 7.11 | 7.15 | 7.02 |
| H11 | 7.18 | 7.18 | 7.18 | 7.12 |
| H14(CH3) | 2.26 | 2.26 | 2.27 | 2.33 |
| H15(CH3) | 2.31 | 2.32 | 2.32 | 2.31 |
| GH1 | 4.71 | 5.45 | 4.69 | |
| GH2 | 3.92 | 3.74 | 3.73 | |
| GH3 | 3.35 | 3.69 | 3.41 | |
| GH4 | 3.53 | 3.65 | 3.38 | |
| GH5 |
| 3.56 | 3.96 | 2.81 |