Precipitant | Precipitant Dose | Precipitant Interval | Object | Object Dose | AUC Ratios Change | Range of AUC Ratios Change |
---|---|---|---|---|---|---|
mg | ||||||
Avasimibe | 50 mg/day (7 d) | N.A. | Midazolam | 2 | 0.27 | |
Avasimibe | 750 mg/day (7 d) | N.A. | Midazolam | 2 | 0.06 | |
Azithromycin (n = 3) | 500 mg (3 d) | q.d. | Midazolam | 15 | 1.1 | 0.87–1.3 |
Azithromycin | 250 mg (2 d) | q.d. | Triazolam | 0.125 | 1 | |
Bosentan | 125 mg (5.5 d) | b.i.d. | Simvastatin | 40 | 0.66 | |
Carbamazepine | 300 mg (14 d) | b.i.d. | Simvastatin | 80 | 0.26 | |
Cimetidine (n = 3) | 400 mg (1.5 d) | b.i.d. | Midazolam | 15 | 1.7 | 1.3–2.0 |
Clarithromycin | 250 mg (5 d) | b.i.d. | Midazolam | 15 | 3.6 | |
Clarithromycin (n = 2) | 500 mg (7 d) | b.i.d. | Midazolam | 8 | 7 | 5.5–8.4 |
Clarithromycin | 500 mg (9 d) | b.i.d. | Simvastatin | 40 | 10 | |
Clarithromycin | 500 mg (2 d) | b.i.d. | Triazolam | 0.125 | 5.3 | |
Cyclosporine | 1.1–3.8 mg/kg/day | N.A. | Simvastatin | 20 | 2.6 | |
Cyclosporine | 236 mg/day (7 M) | N.A. | Simvastatin | 5–10 | 8 | |
Diltiazem | 60 mg (2 d) | t.i.d. | Midazolam | 15 | 3.8 | |
Diltiazem | 60 mg (6 d) | t.i.d. | Nifedipine | 20 | 3 | |
Diltiazem | 120 mg (2 W) | b.i.d. | Simvastatin | 20 | 4.8 | |
Diltiazem (n = 2) | 60 mg | t.i.d. | Triazolam | 0.25 | 2.8 | 2.3–3.4 |
Erythromycin | 200 mg (7 d) | q.i.d. | Midazolam | 5 | 3.3 | |
Erythromycin (n = 2) | 500 mg (7 d) | t.i.d. | Midazolam | 15 | 4.1 | 3.8–4.4 |
Erythromycin | 500 mg (2 d) | b.i.d. | Triazolam | 0.125 | 3.8 | |
Erythromycin | 500 mg (2 d) | t.i.d. | Simvastatin | 40 | 6.2 | |
Erythromycin | 333 mg (3 d) | t.i.d. | Triazolam | 0.5 | 2.1 | |
Ethinyl estradiol | 30 ug (10 d) | Daily | Midazolam | 7.5 | 1.2 | |
Fluconazole | 200 mg (5 d) | q.d. | Midazolam | 7.5 | 3.6 | |
Fluconazole (n = 2) | 400 mg | Single dose | Midazolam | 3 | 4.3 | 3.7–4.9 |
Fluconazole | 200 mg/day | N.A. | Nifedipine | 40 | 2.7 | |
Fluconazole (n = 3) | 100 mg (4 d) | q.d. | Triazolam | 0.25 | 3.2 | 2.1–4.4 |
Fluoxetine | 60 mg (12 d) | q.d. | Midazolam | 10 | 0.87 | |
Fluoxetine | 60 mg (8 d) | q.d. | Triazolam | 0.25 | 1 | |
Itraconazole (n = 3) | 200 mg (4 d) | q.d. | Midazolam | 7.5 | 7.9 | 6.2–11 |
Itraconazole | 200 mg (4 d) | q.d. | Simvastatin | 40 | 10 | |
Itraconazole (n = 4) | 200 mg | Single dose | Triazolam | 0.25 | 3.9 | 3.1–4.5 |
Ketoconazole | 200 mg (1.5 d) | b.i.d. | Midazolam | 6 | 13.6 | 13.6 |
Ketoconazole (n = 3) | 200 mg | Single dose | Midazolam | 2 | 6.8 | 5.2–8.7 |
Ketoconazole (n = 2) | 400 mg | q.d. | Midazolam | 5.5 | 12.6 | 9.5–16 |
Ketoconazole (n = 3) | 200 mg | b.i.d. | Triazolam | 0.125 | 15.1 | 9.2–22 |
Mibefradil | 100 mg | Single dose | Midazolam | 2 | 8.9 | |
Mibefradil | 50 mg (3 d) | q.d. | Triazolam | 0.25 | 8.4 | |
Modafinil | 200–400 mg (28 d) | q.d. | Triazolam | 0.125 | 0.42 | |
Nafcillin | 500 mg (5 d) | q.i.d. | Nifedipine | 10 | 0.37 | |
Nelfinavir | 1250 mg (14 d) | b.i.d. | Simvastatin | 20 | 6.1 | |
Nifedipine | 60 mg | Single dose | Cerivastatin | 0.3 | 1 | |
Phenobarbital | 100 mg/day (8 d) | q.d. | Nifedipine | 20 | 0.39 | |
Phenytoin | 150–300 mg | b.i.d. | Midazolam | 15 | 0.06 | |
Pioglitazone | 45 mg (24 d) | q.d. | Simvastatin | 80 | 0.98 | |
Pleconaril | 400 mg (6 d) | t.i.d. | Midazolam | 5 | 0.65 | |
Rifampin (n = 2) | 600 mg (5 d) | q.d. | Midazolam | 15 | 0.03 | 0.02–0.04 |
Rifampin | 600 mg (7 d) | q.d. | Nifedipine | 20 | 0.08 | |
Rifampin (n = 2) | 600 mg (9 d) | q.d. | Simvastatin | 40 | 0.12 | 0.09–0.14 |
Rifampin | 600 mg (5 d) | q.d. | Triazolam | 0.5 | 0.05 | |
Ritonavir (n = 3) | 200 mg | b.i.d. | Triazolam | 0.125 | 27 | 20–41 |
Rosiglitazone | 8 mg (14 d) | q.d. | Nifedipine | 20 | 0.88 | |
Roxithromycin | 300 mg (6 d) | q.d. | Midazolam | 15 | 1.5 | |
Saquinavir | 1200 mg (5 d) | t.i.d. | Midazolam | 7.5 | 5.2 | |
Troglitazone | 400 mg (24 d) | q.d. | Simvastatin | 40 | 0.62 | |
Troleandomycin | 1 g (7.5 d) | b.i.d. | Triazolam | 0.25 | 3.8 | |
Verapamil | 80 mg (2 d) | t.i.d. | Midazolam | 15 | 2.9 | |
Verapamil | 80 mg (2 d) | t.i.d. | Simvastatin | 40 | 4.7 |
|
d, days; M, months; W, weeks; N.A., not applicable