TABLE 1

Literature compounds dosing regimen information


Precipitant

Precipitant Dose

Precipitant Interval

Object

Object Dose

AUC Ratios Change

Range of AUC Ratios Change
mg
Avasimibe 50 mg/day (7 d) N.A. Midazolam 2 0.27
Avasimibe 750 mg/day (7 d) N.A. Midazolam 2 0.06
Azithromycin (n = 3) 500 mg (3 d) q.d. Midazolam 15 1.1 0.87–1.3
Azithromycin 250 mg (2 d) q.d. Triazolam 0.125 1
Bosentan 125 mg (5.5 d) b.i.d. Simvastatin 40 0.66
Carbamazepine 300 mg (14 d) b.i.d. Simvastatin 80 0.26
Cimetidine (n = 3) 400 mg (1.5 d) b.i.d. Midazolam 15 1.7 1.3–2.0
Clarithromycin 250 mg (5 d) b.i.d. Midazolam 15 3.6
Clarithromycin (n = 2) 500 mg (7 d) b.i.d. Midazolam 8 7 5.5–8.4
Clarithromycin 500 mg (9 d) b.i.d. Simvastatin 40 10
Clarithromycin 500 mg (2 d) b.i.d. Triazolam 0.125 5.3
Cyclosporine 1.1–3.8 mg/kg/day N.A. Simvastatin 20 2.6
Cyclosporine 236 mg/day (7 M) N.A. Simvastatin 5–10 8
Diltiazem 60 mg (2 d) t.i.d. Midazolam 15 3.8
Diltiazem 60 mg (6 d) t.i.d. Nifedipine 20 3
Diltiazem 120 mg (2 W) b.i.d. Simvastatin 20 4.8
Diltiazem (n = 2) 60 mg t.i.d. Triazolam 0.25 2.8 2.3–3.4
Erythromycin 200 mg (7 d) q.i.d. Midazolam 5 3.3
Erythromycin (n = 2) 500 mg (7 d) t.i.d. Midazolam 15 4.1 3.8–4.4
Erythromycin 500 mg (2 d) b.i.d. Triazolam 0.125 3.8
Erythromycin 500 mg (2 d) t.i.d. Simvastatin 40 6.2
Erythromycin 333 mg (3 d) t.i.d. Triazolam 0.5 2.1
Ethinyl estradiol 30 ug (10 d) Daily Midazolam 7.5 1.2
Fluconazole 200 mg (5 d) q.d. Midazolam 7.5 3.6
Fluconazole (n = 2) 400 mg Single dose Midazolam 3 4.3 3.7–4.9
Fluconazole 200 mg/day N.A. Nifedipine 40 2.7
Fluconazole (n = 3) 100 mg (4 d) q.d. Triazolam 0.25 3.2 2.1–4.4
Fluoxetine 60 mg (12 d) q.d. Midazolam 10 0.87
Fluoxetine 60 mg (8 d) q.d. Triazolam 0.25 1
Itraconazole (n = 3) 200 mg (4 d) q.d. Midazolam 7.5 7.9 6.2–11
Itraconazole 200 mg (4 d) q.d. Simvastatin 40 10
Itraconazole (n = 4) 200 mg Single dose Triazolam 0.25 3.9 3.1–4.5
Ketoconazole 200 mg (1.5 d) b.i.d. Midazolam 6 13.6 13.6
Ketoconazole (n = 3) 200 mg Single dose Midazolam 2 6.8 5.2–8.7
Ketoconazole (n = 2) 400 mg q.d. Midazolam 5.5 12.6 9.5–16
Ketoconazole (n = 3) 200 mg b.i.d. Triazolam 0.125 15.1 9.2–22
Mibefradil 100 mg Single dose Midazolam 2 8.9
Mibefradil 50 mg (3 d) q.d. Triazolam 0.25 8.4
Modafinil 200–400 mg (28 d) q.d. Triazolam 0.125 0.42
Nafcillin 500 mg (5 d) q.i.d. Nifedipine 10 0.37
Nelfinavir 1250 mg (14 d) b.i.d. Simvastatin 20 6.1
Nifedipine 60 mg Single dose Cerivastatin 0.3 1
Phenobarbital 100 mg/day (8 d) q.d. Nifedipine 20 0.39
Phenytoin 150–300 mg b.i.d. Midazolam 15 0.06
Pioglitazone 45 mg (24 d) q.d. Simvastatin 80 0.98
Pleconaril 400 mg (6 d) t.i.d. Midazolam 5 0.65
Rifampin (n = 2) 600 mg (5 d) q.d. Midazolam 15 0.03 0.02–0.04
Rifampin 600 mg (7 d) q.d. Nifedipine 20 0.08
Rifampin (n = 2) 600 mg (9 d) q.d. Simvastatin 40 0.12 0.09–0.14
Rifampin 600 mg (5 d) q.d. Triazolam 0.5 0.05
Ritonavir (n = 3) 200 mg b.i.d. Triazolam 0.125 27 20–41
Rosiglitazone 8 mg (14 d) q.d. Nifedipine 20 0.88
Roxithromycin 300 mg (6 d) q.d. Midazolam 15 1.5
Saquinavir 1200 mg (5 d) t.i.d. Midazolam 7.5 5.2
Troglitazone 400 mg (24 d) q.d. Simvastatin 40 0.62
Troleandomycin 1 g (7.5 d) b.i.d. Triazolam 0.25 3.8
Verapamil 80 mg (2 d) t.i.d. Midazolam 15 2.9
Verapamil
80 mg (2 d)
t.i.d.
Simvastatin
40
4.7

  • d, days; M, months; W, weeks; N.A., not applicable