Precipitant | DDI (Observed) | ki | kinact | Predicted AUC′PO/AUCPO (TDI) | GFE |
---|---|---|---|---|---|
μM | min–1 | ||||
Azithromycin | 1.1 | 19 | 0.005 | 1.2 | 1.1 |
Azithromycin | 1.0 | 19 | 0.005 | 1.2 | 1.2 |
Clarithromycin | 3.6 | 14 | 0.028 | 7.3 | 2.0 |
Clarithromycin | 7.0 | 14 | 0.028 | 7.9 | 1.1 |
Clarithromycin | 5.3 | 14 | 0.028 | 7.0 | 1.3 |
Clarithromycin | 10 | 14 | 0.028 | 9.1 | 1.1 |
Cyclosporine | 8.0 | 8.9 | 0.025 | 7.6 | 1.1 |
Cyclosporine | 2.6 | 8.9 | 0.025 | 4.3 | 1.7 |
Diltiazem | 3.8 | 3.3 | 0.070 | 6.1 | 1.6 |
Diltiazem | 3.0 | 3.3 | 0.070 | 6.1 | 2.0 |
Diltiazem | 4.8 | 3.3 | 0.070 | 8.1 | 1.7 |
Diltiazem | 2.8 | 3.3 | 0.070 | 6.1 | 2.2 |
Erythromycin | 3.3 | 13 | 0.025 | 3.0 | 1.1 |
Erythromycin | 4.1 | 13 | 0.025 | 4.5 | 1.1 |
Erythromycin | 3.8 | 13 | 0.025 | 4.5 | 1.2 |
Erythromycin | 6.2 | 13 | 0.025 | 4.5 | 1.4 |
Erythromycin | 2.1 | 13 | 0.025 | 7.9 | 3.7 |
Ethinyl estradiol | 1.2 | 18 | 0.040 | 1.1 | 1.1 |
Fluoxetine | 0.9 | 5.3 | 0.017 | 3.5 | 4.1 |
Fluoxetine | 1.0 | 5.3 | 0.017 | 3.5 | 3.5 |
Mibefradil | 8.9 | 2.3 | 0.400 | 14 | 1.6 |
Mibefradil | 8.4 | 2.3 | 0.400 | 14 | 1.7 |
Nelfinavir | 6.1 | 4.0 | 0.260 | 14 | 2.3 |
Pioglitazone | 1.0 | 10 | 0.011 | 5.5 | 5.6 |
Raloxifene | 1.0 | 9.9 | 0.160 | 1.0 | 1.0 |
Ritonavir | 27 | 0.04 | 0.330 | 14 | 1.9 |
Rosiglitazone | 0.88 | 12 | 0.020 | 2.4 | 2.7 |
Roxithromycin | 1.5 | 72 | 0.023 | 4.3 | 2.9 |
Saquinavir | 5.2 | 0.35 | 0.170 | 14 | 2.6 |
Troglitazone | 0.62 | 5.0 | 0.335 | 14 | 22 |
Troleandomycin | 3.8 | 1.3 | 0.032 | 6.4 | 1.7 |
Verapamil | 2.9 | 2.9 | 0.150 | 10 | 3.5 |
Verapamil | 4.7 | 2.9 | 0.150 | 10 | 2.2 |
Geometric mean fold error |
|
|
|
|
2.7
|
Values highlighted in bold are above 2-fold