Hepatic luciferase activity in rats receiving hydrodynamics-based injections
All data are expressed in arbitrary light units (normalized for Renilla activity) as mean ± S.D. of determinations from hepatic lysates prepared from three or four rats. Statistically significant effects of MC are summarized in Fig. 1.
Plasmid Delivered | 6 h | 24 h | 72 h | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Vehicle | MC | Vehicle | MC | Vehicle | MC | ||||
| pGL3-Basic | N.D. | N.D. | 0.60 ± 0.07 | 0.71 ± 0.08 | 0.21 ± 0.01 | 0.28 ± 0.10 | |||
| pGudluc1.1 | N.D. | N.D. | 0.15 ± 0.02 | 305.95 ± 62.22 | 0.10 ± 0.03 | 335.05 ± 256.84 | |||
| (-10.1-2C11) | 5.29 ± 3.62 | 3.00 ± 1.79 | 153.72 ± 19.73 | 74.84 ± 50.13 | 4225.88 ± 2386.38 | 1330.27 ± 485.98 | |||
| (-5.6-2C11) | N.D. | N.D. | 1.95 ± 0.25 | 0.70 ± 0.36 | 49.65 ± 38.53 | 11.79 ± 1.74 | |||
| (-2.4-2C11) | N.D. | N.D. | 3.50 ± 0.42 | 2.22 ± 0.51 | 1.48 ± 0.83 | 2.28 ± 1.32 | |||
N.D., not determined.