TABLE 1

Cumulative food intake and plasma transaminase levels in mice fed bile acid-supplemented chow

Mice were fed 0.4% bile acid-supplemented chow for 5 days (n = 5 for each condition). Values represent mean ± S.D.

Bile Acid in DietCumulative Food IntakePlasma ALTPlasma AST
g IU/l
Control16.7 ± 0.510.8 ± 12.342.5 ± 14.7
CDCA16.0 ± 0.518.0 ± 13.679.9 ± 31.9
CA12.2 ± 0.923.1 ± 5.2101.5 ± 14.8
    pValue<0.001a
DCA13.3 ± 0.926.3 ± 9.4115.7 ± 50.8
    pValue<0.001a
LCA14.5 ± 1.411.5 ± 2.084.6 ± 16.7
    pValue<0.001a
  • ALT, alanine aminotransferase; AST, aspartate aminotransferase.

  • a Comparison with control chow.