Km, Vmax, and hepatic clearance (Vmax/Km) estimates for Type I pyrethroids incubated in rat hepatic microsomes
Values were obtained using three different pooled microsomal samples.
Pyrethroid | Isomer | Km | Vmax | Vmax/Km |
|---|---|---|---|---|
| μM | nmol/min/mg microsomal protein | ml/min/mg microsomal protein | ||
| Bifenthrin | 100% cis | 5.42 | 0.64 | 0.12 |
| (3.25-8.52)a | (0.56-0.74) | |||
| S-Bioallethrin | 100% trans | 31.11 | 4.40 | 0.14 |
| (8.38-233.16) | (2.81-12.59) | |||
| Bioresmethrin | 96% trans | 3.87 | 0.32 | 0.08 |
| 2% trans | (2.33-7.07) | (0.25-0.44) | ||
| cis-Permethrin | 100% cis | 3.70 | 0.14 | 0.04 |
| (1.60-9.20) | (0.11-0.20) | |||
| trans-Permethrin | 96% trans | 9.03 | 0.97 | 0.11 |
|
| 4% cis | (5.66-15.42) | (0.82-1.23) |
|
↵ a 95% confidence interval.